Issue Date: Feb 27, 2018. Country: United States. Invented By: Helene Benveniste, Rashid Deane, Jeffrey J Iliff, Maiken Nedergaard. Patent Title: Method of Treating and Preventing Brain Impairment using Na+-K+2Cl-Cotransporter Isoform 1 Inhibitors. Patent #: 2887806. Issue Date: Nov 13, 2019..