Slowly consume Dose 1 within 30 minutes. Refill the container with 16 oz. of a clear liquid of your choice. Again, slowly finish all of it within 30 minutes. Repeat step 3 with Plenvu Dose 2 at 10:00 pm the night before the procedure. F or an AFTERNOON Colonoscopy (after 12:00 pm), at 6:00 pm the evening before your procedure, follow step 3..