Itai-itai disease (イタイイタイ病, itai-itai byō, "it hurts-it hurts disease") was the name given to the mass cadmium poisoning of Toyama Prefecture, Japan, starting around 1912.The term "itai-itai disease" was coined by locals for the severe pains (Japanese: 痛い itai) people with the condition felt in the spine and joints.Cadmium (Cd) poisoning can also cause softening of the bones ....