Follow 8th Street to Walnut Street and turn right. • Follow Walnut Street to 11th Street and turn right. • Follow 11th Street to Jefferson's campus. From Main Line. • Take Route 476 North to exit 16A (Route 76 East/Schuylkill Expressway) to Philadelphia. • Take Exit 344 (Central Phila./676 East) - a left-lane exit..