Acne can be unsightly and painful. In addition to the physical toll, it can also saddle sufferers with poor self-esteem and even depression. A drug called Accutane ® (isotretinoin) offers acne sufferers a potent, highly-effective option for clearing even the most stubborn acne. For more than 20 years, Accutane ® has successfully helped patients with severe recalcitrant nodular acne..