Copper often serves as a redox cofactor for enzymes such as cytochrome c oxidase in the mitochondrial electron transport chain (ETC) and Cu, Zn-superoxide dismutases (e.g., Sod1) ().As a redox cofactor, copper cycles between the cupric (Cu 2+) and cuprous (Cu 1+) states.However, it is the cuprous form that is trafficked and sensed intracellularly, suggesting a need to maintain cellular copper ....