best diabetes drug for weight loss 🙋treatment nhs. Various studies investigated the efficacy of SGLT-2i (empagliflozin [48, 49], dapagliflozin [50, 51], canagliflozin [] and the dual SGLT-1 and -2i sotagliflozin [53, 54]) in the treatment of T1DM.All studies reported a significant decrease in HbA1c [48,49,50,51,52,53,54] and some also reductions in body weight [49, 51,52,53] and daily ....