We thank Dr. Vinciguerra for his interest in our article regarding synergistic inhibition of hepatocellular carcinoma (HCC) growth by cotargeting the enzymatic activities of histone deacetylases (HDACs) and poly(ADP-ribose) polymerases (PARPs) in HCC cell lines. 1 The amplified in liver cancer 1 (ALC1, also known as CHD1L) oncogene, originally isolated in primary HCC, is frequently amplified ....