Portal Hypertension - ncbi.nlm.nih.gov

A large multicenter RCT of timolol, NSBB, versus placebo performed in patients with cirrhosis and portal hypertension but without varices, showed a similar rate of development of varices in both treatment groups, with a higher rate of adverse events in the timolol group. 1 Therefore, NSBB are not recommended for the prevention of varices..

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