A Novel non-PPARgamma Insulin Sensitizer: MLR-1023 ...

Aim: MLR-1023, called Tolimidone when evaluated unsuccessfully by Pfizer for gastric ulcer disease, has been repurposed as a novel oral insulin sensitizer with its effects mediated by selective activation of Lyn kinase. We aimed to evaluate the optimal dose, efficacy and safety of MLR-1023 in patients with type 2 diabetes. Methods: Type 2 diabetes patients (18-75 years) on diet/exercise ....

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