Hoag Hospital Irvine. 16200 Sand Canyon Avenue. Irvine, CA 92618. 949-764-HOAG (4624) Hoag Hospital Irvine, providing a wide range of inpatient and outpatient services, including a fully staffed emergency room, is located on Sand Canyon Avenue and Alton Parkway, just off the 405 freeway. Hoag Orthopedic Institute..