We selected two human papillomavirus (HPV)-negative HNSCC cell lines (SCC-25 and CAL-33) that harbor many genetic alterations present in the HNSCC patient population and that have previously been shown to have RNA profiles highly correlated with those of HNSCC patients (Spearman correlation = 0.66 and 0.69 for CAL-33 and SCC-25, respectively ....